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Progression after targeted therapyLung Cancer

Lung cancer progression after targeted therapy

Targeted therapy no longer works. What is usually checked first?

After progression to targeted therapy, re-examination of tissue or blood is usually considered to look for resistance mechanisms before selecting the next step.

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What changes at this stage

  • The mechanism of resistance determines whether there are further targeted therapy options.
  • The location of progression influences whether local action is considered.
  • General condition influences the choice between continued therapy and symptom control.

Options that are usually discussed

  • Molecular reexamination

    Re-sequencing of tissue or blood looks for changes such as T790M, C797S, or MET.

  • Next targeted therapy

    If a suitable target is found, subsequent inhibitors can be discussed.

  • Switch categories or clinical trials

    Chemotherapy, immunotherapy, or clinical studies may be discussed next.

The decision remains with your doctor

This page explains the options that may be discussed; it does not choose one for you.

Practical next steps

  • Request a recent re-examination of tissue or blood markers.
  • Ask about resistance findings that need to be confirmed.
  • Assess concordance with studies targeting the mechanism.

Questions for your oncologist

  • Is molecular re-examination necessary, and from what samples?
  • What resistance mechanism is most likely in my case?
  • Are there still targeted therapy options?
  • Are there clinical trials targeting these changes?

Relevant biomarkers

Treatment categories

Drugs commonly discussed

Supporting guides

Clinical trials

Registry studies for this group

International-patient access and site readiness have not been verified for any study.

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