Decision situations
Start with your situation, not only the disease name
These pages address questions that arise at specific points in the disease journey, such as after surgery, when targeted therapy stops working, or when brain lesions are found.
Lung Cancer
Cancer page- Newly diagnosed
Newly diagnosed lung cancer
The initial stage after diagnosis is not choosing a drug, but rather ensuring the diagnosis, histology type, stage and complete biological markers.
I just received a diagnosis of lung cancer. What do you need to confirm first?
- Still operable
Lung cancer that is still operable
At a stage that is still operable, the discussion centers on the appropriateness of the procedure, the type of surgery, and whether additional therapy is needed afterwards.
My tumor was assessed as operable. What to consider before and after?
- Locally advanced
Locally advanced lung cancer
In locally advanced disease, discussions often combine radiotherapy and systemic therapy, with the sequence depending on the condition and markers.
My disease is locally advanced and has not spread far. What options are usually discussed?
- Metastatic disease
Metastatic lung cancer
In metastatic disease, biomarkers and general condition are the primary determinants of therapy category, and clinical trials are often part of the discussion.
My disease has spread. How are therapy options usually structured?
- Oligometastatic
Oligometastatic lung cancer
When spread is limited to a few locations, discussions may include local therapy targeted at the lesion, often in conjunction with systemic therapy.
My deployment is limited to a few locations. Are local measures still being discussed?
- After surgery
After lung cancer surgery
After surgery, pathology results and lymph node involvement determine whether additional therapy is discussed and how closely monitoring is performed.
The operation is complete. What determines the next step?
- Progression after targeted therapy
Lung cancer progression after targeted therapy
After progression to targeted therapy, re-examination of tissue or blood is usually considered to look for resistance mechanisms before selecting the next step.
Targeted therapy no longer works. What is usually checked first?
- Progression after immunotherapy
Lung cancer progression after immunotherapy
After progression to immunotherapy, it is necessary to determine whether what is occurring is true progression, an unusual response, or side effects related to the immune system.
Immunotherapy no longer controls the disease. What needs to be assessed?
- Spread to the brain
Lung cancer with spread to the brain
Brain involvement changes therapeutic considerations as it influences symptoms, the choice of drugs that penetrate the blood-brain barrier, and the feasibility of targeted radiotherapy.
There is a lesion in the brain. How does this change the therapy plan?
- Spread to bone
Lung cancer with spread to the bones
Spread to the bone can cause pain and increase the risk of fracture, so local treatment and supportive medications are part of the plan.
There is spread to the bones. What to consider?
Stomach Cancer
Cancer page- After chemotherapy is no longer effective
Gastric cancer after chemotherapy no longer gives results
In gastric cancer, the next steps depend on markers such as HER2, PD-L1, MSI/MMR, and CLDN18.2, as well as on the history of previous therapy.
Chemotherapy no longer works on my stomach cancer. What's the next step?
Breast Cancer
Cancer page- Spread to the brain
Lung cancer with spread to the brain
Brain involvement changes therapeutic considerations as it influences symptoms, the choice of drugs that penetrate the blood-brain barrier, and the feasibility of targeted radiotherapy.
There is a lesion in the brain. How does this change the therapy plan?
- Spread to bone
Lung cancer with spread to the bones
Spread to the bone can cause pain and increase the risk of fracture, so local treatment and supportive medications are part of the plan.
There is spread to the bones. What to consider?
- Progression after targeted therapy
Breast cancer progression after HER2 therapy
After progression on HER2 therapy, HER2 status can be reassessed and the next choice depends on the sequence of therapy undertaken and the location of spread.
Anti-HER2 therapy no longer controls the disease. What needs to be reassessed?
Not a diagnosis and not final medical advice. Must be reviewed by a doctor.
Next steps
These suggestions come from links between entries in TanyaKanker's database, not from a medical judgement. Each suggestion includes why it appears.
Next to learn
- Lung Cancer
Cancer type
Reason: Most connected in the oncology graph
- Stomach Cancer
Cancer type
Reason: Most connected in the oncology graph
- Lymphoma
Cancer type
Reason: Most connected in the oncology graph
- Multiple Myeloma
Cancer type
Reason: Most connected in the oncology graph
- ALK
Biomarker
Reason: Highest discovery priority among markers
- BCMA
Biomarker
Reason: Highest discovery priority among markers
- BCR-ABL
Biomarker
Reason: Highest discovery priority among markers
- BRAF
Biomarker
Reason: Highest discovery priority among markers
To check
- Testing Osimertinib as a Treatment for Lung Cancers With an EGFR Exon 20 Change
NCT03191149 - Phase 2
Reason: Registry update in the last 30 days (2026-10-15)
- A Study of Mevrometostat for Treatment of Relapsed/Refractory SCLC, Castration Resistant Prostate Cancer, and Follicular Lymphoma
NCT03460977 - Phase 1
Reason: Registry update in the last 30 days (2026-10-15)
- Testing the Addition of a Type of Drug Called Immunotherapy to the Usual Chemotherapy Treatment for Non-small Cell Lung Cancer, an ALCHEMIST Treatment Trial (Chemo-IO [ACCIO])
NCT04267848 - Phase 3
Reason: Registry update in the last 30 days (2026-10-15)
- Testing the Addition of an Anti-cancer Drug, Lenalidomide, to the Usual Combination Chemotherapy Treatment ("EPOCH") for Adult T-Cell Leukemia-Lymphoma (ATLL)
NCT04301076 - Phase 1
Reason: Registry update in the last 30 days (2026-10-15)
What you can do
- Upload medical reports
Build a case summary in twelve steps
Reason: Often the most useful next step after reading this page
- Request a second opinion
Review of the treatment plan
Reason: Relevant when a treatment plan is being considered
- Consult a navigator
A request is recorded with this page context
Reason: For asking the next step directly
Recently updated
- Testing Osimertinib as a Treatment for Lung Cancers With an EGFR Exon 20 Change
NCT03191149 - Phase 2
Date: Registry update in the last 30 days (2026-10-15)
- A Study of Mevrometostat for Treatment of Relapsed/Refractory SCLC, Castration Resistant Prostate Cancer, and Follicular Lymphoma
NCT03460977 - Phase 1
Date: Registry update in the last 30 days (2026-10-15)
- Testing the Addition of a Type of Drug Called Immunotherapy to the Usual Chemotherapy Treatment for Non-small Cell Lung Cancer, an ALCHEMIST Treatment Trial (Chemo-IO [ACCIO])
NCT04267848 - Phase 3
Date: Registry update in the last 30 days (2026-10-15)
- Testing the Addition of an Anti-cancer Drug, Lenalidomide, to the Usual Combination Chemotherapy Treatment ("EPOCH") for Adult T-Cell Leukemia-Lymphoma (ATLL)
NCT04301076 - Phase 1
Date: Registry update in the last 30 days (2026-10-15)
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