Skip to main content
TanyaKanker
Progression after targeted therapyBreast Cancer

Breast cancer progression after HER2 therapy

Anti-HER2 therapy no longer controls the disease. What needs to be reassessed?

After progression on HER2 therapy, HER2 status can be reassessed and the next choice depends on the sequence of therapy undertaken and the location of spread.

Upload Medical ReportPrepare questions for your doctor

Not a diagnosis and not final medical advice. Must be reviewed by a doctor.

What changes at this stage

  • HER2 status can change so re-examination is sometimes guided by taking a new sample.
  • Brain involvement alters drug selection considerations.
  • The order of previous drug categories influences subsequent choices.

Options that are usually discussed

  • Reassess marker status

    Sampling from recent lesions may be performed to confirm HER2 status.

  • Next category

    Antibody-drug conjugates and other combinations are discussed according to therapeutic history.

  • Treatment of brain involvement

    In diseases with brain lesions, the choice of therapy is tailored to penetration into the central nervous system.

The decision remains with your doctor

This page explains the options that may be discussed; it does not choose one for you.

Practical next steps

  • Request reassessment of HER2 scores from recent samples whenever possible.
  • Note the order of all anti-HER2 therapy that has been undertaken.
  • Ask if there are clinical trials that screen for current marker status.

Questions for your oncologist

  • Do HER2 scores need to be reassessed from newer samples?
  • What categories of medications have I never taken?
  • Is there brain involvement that changes choices?
  • Are there appropriate clinical trials?

Relevant biomarkers

Treatment categories

Drugs commonly discussed

Supporting guides

Would you like to discuss this situation with someone?

Send a request with the context from this page so the documents and questions to prepare can be identified sooner.

Consult via WhatsAppUpload Medical Reports

After submission, a human navigator reviews your request and contacts you through your chosen channel. The WhatsApp message already includes this page context, so you do not need to explain from the beginning.

Clinical data is not requested in the form and is not sent to analytics. Do not send medical reports through WhatsApp or email; use the secure upload page. We do not promise eligibility or any treatment outcome.

Next steps

These suggestions come from links between entries in TanyaKanker's database, not from a medical judgement. Each suggestion includes why it appears.

Next to learn

To check

What you can do

  • Upload medical reports

    Build a case summary in twelve steps

    Reason: Often the most useful next step after reading this page

  • Request a second opinion

    Review of the treatment plan

    Reason: Relevant when a treatment plan is being considered

  • Consult a navigator

    A request is recorded with this page context

    Reason: For asking the next step directly

Recently updated

Want to follow changes on this topic? Save the page or follow the topic so it is easy to find again. View saved items.