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After chemotherapy is no longer effectiveStomach Cancer

Gastric cancer after chemotherapy no longer gives results

Chemotherapy no longer works on my stomach cancer. What's the next step?

In gastric cancer, the next steps depend on markers such as HER2, PD-L1, MSI/MMR, and CLDN18.2, as well as on the history of previous therapy.

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Not a diagnosis and not final medical advice. Must be reviewed by a doctor.

What changes at this stage

  • Marker status may change after therapy so re-examination is sometimes discussed.
  • Categories of anti-HER2 antibodies and other pathways are only relevant when markers are appropriate.
  • General condition and tolerance to previous chemotherapy influence the choice.

Options that are usually discussed

  • Recheck markers

    Re-sampling may be considered to ensure up-to-date marker status.

  • The next category of therapy

    Targeted therapy, immunotherapy, or other combinations are discussed according to marker results.

  • Clinical trials and cellular therapy

    Studies that screen for specific markers, including cellular therapies, may be discussed.

The decision remains with your doctor

This page explains the options that may be discussed; it does not choose one for you.

Practical next steps

  • Ensure the latest marker reports are available, including CLDN18.2 when possible.
  • Ask if a network recheck is necessary.
  • Assess concordance with studies that screen for the marker.

Questions for your oncologist

  • Have my HER2, PD-L1, MSI/MMR, and CLDN18.2 status been checked on the latest samples?
  • Would rechecking the network help at this stage?
  • What is the next category of therapy worth discussing?
  • Is there a clinical test that screens for my markers?

Relevant biomarkers

Treatment categories

Drugs commonly discussed

Supporting guides

Clinical trials

Registry studies for this group

International-patient access and site readiness have not been verified for any study.

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Next steps

These suggestions come from links between entries in TanyaKanker's database, not from a medical judgement. Each suggestion includes why it appears.

Next to learn

To check

What you can do

  • Upload medical reports

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    Reason: Often the most useful next step after reading this page

  • Request a second opinion

    Review of the treatment plan

    Reason: Relevant when a treatment plan is being considered

  • Consult a navigator

    A request is recorded with this page context

    Reason: For asking the next step directly

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