BCR-ABL
Other names: Philadelphia chromosome, kromosom Philadelphia, BCR-ABL1
The BCR-ABL transcript is a defining marker in chronic myeloid leukemia and some acute lymphoblastic leukemia.
Not a diagnosis and not final medical advice. Must be reviewed by a doctor.
Plain explanation
BCR-ABL is formed when two chromosomes exchange parts and produces a continuously active growth signal. This marker is found through blood or bone marrow examination.
Clinical meaning
The presence of BCR-ABL opens up a category of specific tyrosine kinase inhibitors. Transcript levels are also used to monitor the depth of response to therapy.
Testing methods
- BCR-ABL PCR
A molecular test that measures the BCR-ABL transcript and monitors response in certain leukemias.
- FISH (fluorescence in situ hybridisation)
A test that detects changes in the number or arrangement of genetic material in tumour cells.
- Next-generation sequencing (NGS)
A test that reads many genes from one tumour sample to find actionable changes.
A negative result does not always mean the marker is absent
Test sensitivity differs by sample type and method. Results need to be read together with the pathology report and clinical condition.
What needs verification
- The latest quantitative values and international scales used by laboratories.
- Time span of examination to read response trends.
- Whether additional changes were discovered that could influence the choice of inhibitor.
- Ask how these results change the monitoring plan.
Clinical trials
Studies mentioning this marker
Filtered from public study descriptions. Access status and site readiness remain unverified.
NO DATA
No studies in the latest registry data mention this marker in their description.
Check options based on your result
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Next steps
These suggestions come from links between entries in TanyaKanker's database, not from a medical judgement. Each suggestion includes why it appears.
Next to learn
- Leukemia
Cancer type
Reason: Related through a biomarker
- Major BCR-ABL transcript (e13a2 or e14a2)
Molecular alteration
Reason: Related through a biomarker
- BCR-ABL T315I
Molecular alteration
Reason: Related through a biomarker
- Targeted therapy
Treatment category
Reason: Related through a biomarker
- Dasatinib
Drug
Reason: Targets this marker
- Imatinib
Drug
Reason: Targets this marker
To check
- FISH (fluorescence in situ hybridisation)
Diagnostic test
Reason: Diperiksa melalui
- Next-generation sequencing (NGS)
Diagnostic test
Reason: Diperiksa melalui
- BCR-ABL PCR
Diagnostic test
Reason: Diperiksa melalui
- Check medical report completeness
Tool
Reason: Prepare documents that still need confirmation
- Prepare questions for your doctor
Tool
Reason: Bring clear questions to the next conversation
What you can do
- Upload medical reports
Build a case summary in twelve steps
Reason: Often the most useful next step after reading this page
- Request a second opinion
Review of the treatment plan
Reason: Relevant when a treatment plan is being considered
- Consult a navigator
A request is recorded with this page context
Reason: For asking the next step directly
Recently updated
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Cancer page
Date: Data revision 2026-09-10
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Date: Registry update in the last 30 days (2026-10-15)
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