GPC3
Other names: glypican-3
GPC3 is a surface protein often found in hepatocellular carcinoma and is being studied as a therapy target.
Not a diagnosis and not final medical advice. Must be reviewed by a doctor.
Plain explanation
GPC3 is a protein that appears frequently in certain types of liver cancer. This protein is also used as an additional marker in pathological examinations.
Clinical meaning
GPC3 expression helps confirm tumor origin in doubtful cases and is a target for therapeutic research, including cellular therapy. Some of the approaches are still in the clinical research stage.
Testing methods
- Immunohistochemistry (IHC)
A test that uses antibodies to mark specific proteins in tumour tissue.
- Next-generation sequencing (NGS)
A test that reads many genes from one tumour sample to find actionable changes.
A negative result does not always mean the marker is absent
Test sensitivity differs by sample type and method. Results need to be read together with the pathology report and clinical condition.
What needs verification
- GPC3 staining results in the latest pathology report.
- Approval status and availability of therapies targeting GPC3, as some are still under investigation.
- Compliance with clinical trial criteria, including history of previous therapy.
Clinical trials
Studies mentioning this marker
Filtered from public study descriptions. Access status and site readiness remain unverified.
NO DATA
No studies in the latest registry data mention this marker in their description.
Check options based on your result
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Next steps
These suggestions come from links between entries in TanyaKanker's database, not from a medical judgement. Each suggestion includes why it appears.
Next to learn
- Liver Cancer
Cancer type
Reason: Related through a biomarker
- GPC3 positive
Molecular alteration
Reason: Related through a biomarker
- CAR-T (chimeric antigen receptor T-cell therapy)
Treatment category
Reason: Related through a biomarker
- Targeted therapy
Treatment category
Reason: Related through a biomarker
To check
- Immunohistochemistry (IHC)
Diagnostic test
Reason: Diperiksa melalui
- Next-generation sequencing (NGS)
Diagnostic test
Reason: Diperiksa melalui
- Check medical report completeness
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Reason: Prepare documents that still need confirmation
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Reason: Bring clear questions to the next conversation
What you can do
- Upload medical reports
Build a case summary in twelve steps
Reason: Often the most useful next step after reading this page
- Request a second opinion
Review of the treatment plan
Reason: Relevant when a treatment plan is being considered
- Consult a navigator
A request is recorded with this page context
Reason: For asking the next step directly
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