GPRC5D
Other names: G protein-coupled receptor class C group 5 member D
GPRC5D is an alternative marker on myeloma cells used when BCMA targeting is no longer effective.
Not a diagnosis and not final medical advice. Must be reviewed by a doctor.
Plain explanation
GPRC5D is a protein that is quite typical of myeloma cells. These markers are discussed as backup therapeutic targets in diseases that are already widely treated.
Clinical meaning
GPRC5D expression has been the basis for consideration of some bispecific antibody and cellular therapy studies in advanced multiple myeloma.
Testing methods
- Immunohistochemistry (IHC)
A test that uses antibodies to mark specific proteins in tumour tissue.
- Next-generation sequencing (NGS)
A test that reads many genes from one tumour sample to find actionable changes.
A negative result does not always mean the marker is absent
Test sensitivity differs by sample type and method. Results need to be read together with the pathology report and clinical condition.
What needs verification
- Is GPRC5D assessment available at the laboratory used?
- History of previous therapy and whether you have received therapy with similar targets.
- Availability of drugs, because some are still going through research.
Related drugs
- Talquetamab
GPRC5DxCD3 bispecific antibody
A link here means the marker is often part of considering a drug category, not a recommendation to use it.
Clinical trials
Studies mentioning this marker
Filtered from public study descriptions. Access status and site readiness remain unverified.
NO DATA
No studies in the latest registry data mention this marker in their description.
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Next steps
These suggestions come from links between entries in TanyaKanker's database, not from a medical judgement. Each suggestion includes why it appears.
Next to learn
- Multiple Myeloma
Cancer type
Reason: Related through a biomarker
- GPRC5D positive
Molecular alteration
Reason: Related through a biomarker
- CAR-T (chimeric antigen receptor T-cell therapy)
Treatment category
Reason: Related through a biomarker
- Immunotherapy
Treatment category
Reason: Related through a biomarker
- Talquetamab
Drug
Reason: Targets this marker
To check
- Immunohistochemistry (IHC)
Diagnostic test
Reason: Diperiksa melalui
- Next-generation sequencing (NGS)
Diagnostic test
Reason: Diperiksa melalui
- Check medical report completeness
Tool
Reason: Prepare documents that still need confirmation
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Reason: Bring clear questions to the next conversation
What you can do
- Upload medical reports
Build a case summary in twelve steps
Reason: Often the most useful next step after reading this page
- Request a second opinion
Review of the treatment plan
Reason: Relevant when a treatment plan is being considered
- Consult a navigator
A request is recorded with this page context
Reason: For asking the next step directly
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