Pathogenic BRCA1 or BRCA2 variant
A pathogenic BRCA change that affects treatment choices and family risk.
Parent marker: BRCA1 / BRCA2
Not a diagnosis and not final medical advice. Must be reviewed by a doctor.
Clinical meaning
These changes indicate DNA repair weaknesses that can be exploited by the PARP inhibitor category. If inherited genes are found, genetic counseling becomes an important part for the family.
How this finding appears in a report
Checked through sequencing. It is necessary to distinguish whether the changes are found in tumor tissue only or also in inherited genes.
When therapy stops working
Resistance may arise through restoration of DNA repair function or other changes.
What needs verification
- Whether the changes are congenital or only in the tumor.
- Classification of variants in laboratory reports.
- Has genetic counseling been carried out before congenital examination?
Marker context: BRCA1 / BRCA2
BRCA alteration opens up a category of therapies that exploit DNA repair weaknesses in some breast, ovarian, pancreatic and prostate cancers. Screening is also important to assess risk to the family, which requires genetic counseling.
A negative result does not always mean absent
Summary
- Gen
- BRCA1/BRCA2
- Variant
- BRCA1 atau BRCA2 pathogenic variant
- Alteration type
- Mutation
- Discussed in
- Breast Cancer, Pancreatic Cancer
- Updated
- 2026-09-10
Other names in reports
BRCA mutation, germline BRCA, somatic BRCA
Drugs discussed
Treatment categories
Sources
- NCI Dictionary of Cancer Terms(lembaga)
- ClinicalTrials.gov(registry)
Next steps
These suggestions come from links between entries in TanyaKanker's database, not from a medical judgement. Each suggestion includes why it appears.
Next to learn
- BRCA1 / BRCA2
Biomarker
Reason: Related through a biomarker
- Pancreatic Cancer
Cancer type
Reason: Related to this page
- Breast Cancer
Cancer type
Reason: Related to this page
- Olaparib
Drug
Reason: Related to this page
- Targeted therapy
Treatment category
Reason: Related to this page
To check
- Check medical report completeness
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What you can do
- Upload medical reports
Build a case summary in twelve steps
Reason: Often the most useful next step after reading this page
- Request a second opinion
Review of the treatment plan
Reason: Relevant when a treatment plan is being considered
- Consult a navigator
A request is recorded with this page context
Reason: For asking the next step directly
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