FLT3-ITD
A FLT3 change often found in acute myeloid leukemia and discussed in treatment selection.
Parent marker: FLT3
Not a diagnosis and not final medical advice. Must be reviewed by a doctor.
Clinical meaning
FLT3-ITD is among the markers examined in acute myeloid leukemia. The allelic ratio was also noted because it influences the risk discussion.
How this finding appears in a report
Checked via sequencing or PCR on bone marrow or blood samples.
When therapy stops working
Secondary changes in the FLT3 kinase domain may occur following FLT3 inhibitor therapy.
What needs verification
- Complete variant name as written in the laboratory report.
- Examination methods and types of samples used.
- Examination dates were compared with ongoing therapy.
Marker context: FLT3
FLT3 mutations, especially FLT3-ITD, are among the markers examined in acute myeloid leukemia and open the category of FLT3 inhibitors in some therapeutic situations.
A negative result does not always mean absent
Summary
- Gen
- FLT3
- Variant
- FLT3 internal tandem duplication
- Alteration type
- Insertion
- Discussed in
- Leukemia
- Updated
- 2026-09-10
Other names in reports
FLT3-ITD
Drugs discussed
Treatment categories
Sources
- NCI Dictionary of Cancer Terms(lembaga)
- ClinicalTrials.gov(registry)
Next steps
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Next to learn
- FLT3
Biomarker
Reason: Related through a biomarker
- Leukemia
Cancer type
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- Gilteritinib
Drug
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- Midostaurin
Drug
Reason: Related to this page
- Targeted therapy
Treatment category
Reason: Related to this page
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