NTRK fusion
A rare tumour-agnostic fusion that opens the TRK inhibitor category.
Parent marker: NTRK
Not a diagnosis and not final medical advice. Must be reviewed by a doctor.
Clinical meaning
NTRK fusion allows targeted therapy without depending on the organ of origin of the tumor. Because they are rare, discoveries usually come from a wider panel.
How this finding appears in a report
Discovered through a sequencing panel that includes NTRK1, NTRK2, and NTRK3.
When therapy stops working
Changes in the TRK kinase domain may occur following therapy.
What needs verification
- Complete variant name as written in the laboratory report.
- Examination methods and types of samples used.
- Examination dates were compared with ongoing therapy.
Marker context: NTRK
NTRK fusions are tumor-agnostic: if discovered, this marker can form the basis of discussion of targeted therapy without depending on the organ of origin of the tumor.
A negative result does not always mean absent
Summary
- Gen
- NTRK
- Variant
- NTRK1/2/3 fusion
- Alteration type
- Fusion
- Discussed in
- Lung Cancer, Stomach Cancer, Lymphoma
- Updated
- 2026-09-10
Other names in reports
TRK fusion
Drugs discussed
Treatment categories
Sources
- NCI Dictionary of Cancer Terms(lembaga)
- ClinicalTrials.gov(registry)
Clinical trials
Studies mentioning marker NTRK
Filtered from public study descriptions. Access status and site readiness remain unverified.
NCT01639508Phase 2Combination regimen
Cabozantinib in Patients With RET Fusion-Positive Advanced Non-Small Cell Lung Cancer and Those With Other Genotypes: ROS1 or NTRK Fusions or Increased MET or AXL Activity
Lung Cancer | biomarker: ROS1, MET, RET, NTRK
United States7 registry sites
Why this appears: Appears because it is recorded for Lung Cancer, it mentions marker ROS1.
What to verify: Acceptance of patients from outside the local country has not been verified.
- Registry
- Recruiting in registry
- Site
- Not verified
- International access
- Unknown
- Patient match
- Not assessed
Last checked 16 Oktober 2026Source ClinicalTrials.govNCT01639508Not verified
Next steps
These suggestions come from links between entries in TanyaKanker's database, not from a medical judgement. Each suggestion includes why it appears.
Next to learn
- NTRK
Biomarker
Reason: Related through a biomarker
- Stomach Cancer
Cancer type
Reason: Related to this page
- Lung Cancer
Cancer type
Reason: Related to this page
- Entrectinib
Drug
Reason: Related to this page
- Larotrectinib
Drug
Reason: Related to this page
- Targeted therapy
Treatment category
Reason: Related to this page
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