NTRK
Other names: NTRK fusion, TRK fusion, NTRK1, NTRK2, NTRK3
NTRK fusion is very rare, but is a marker that can be discussed across cancer types.
Not a diagnosis and not final medical advice. Must be reviewed by a doctor.
Plain explanation
NTRK fusion is a change that combines the NTRK gene with another gene. Because it is rare, the examination is usually carried out as part of a wider panel.
Clinical meaning
NTRK fusions are tumor-agnostic: if discovered, this marker can form the basis of discussion of targeted therapy without depending on the organ of origin of the tumor.
Testing methods
- Next-generation sequencing (NGS)
A test that reads many genes from one tumour sample to find actionable changes.
- Immunohistochemistry (IHC)
A test that uses antibodies to mark specific proteins in tumour tissue.
- FISH (fluorescence in situ hybridisation)
A test that detects changes in the number or arrangement of genetic material in tumour cells.
A negative result does not always mean the marker is absent
Test sensitivity differs by sample type and method. Results need to be read together with the pathology report and clinical condition.
What needs verification
- Examination methods and types of fusion found.
- Does the panel used really cover NTRK1/2/3?
- Therapy history and current clinical conditions.
- Drug availability: often only through special routes or clinical trials.
Related drugs
- Larotrectinib
Selective TRK inhibitor
- Entrectinib
TRK/ROS1/ALK inhibitor
- Repotrectinib
New generation ROS1/TRK inhibitors
A link here means the marker is often part of considering a drug category, not a recommendation to use it.
Clinical trials
Studies mentioning this marker
Filtered from public study descriptions. Access status and site readiness remain unverified.
NCT01639508Phase 2Combination regimen
Cabozantinib in Patients With RET Fusion-Positive Advanced Non-Small Cell Lung Cancer and Those With Other Genotypes: ROS1 or NTRK Fusions or Increased MET or AXL Activity
Lung Cancer | biomarker: ROS1, MET, RET, NTRK
United States7 registry sites
Why this appears: Appears because it is recorded for Lung Cancer, it mentions marker ROS1.
What to verify: Acceptance of patients from outside the local country has not been verified.
- Registry
- Recruiting in registry
- Site
- Not verified
- International access
- Unknown
- Patient match
- Not assessed
Last checked 16 Oktober 2026Source ClinicalTrials.govNCT01639508Not verified
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Next steps
These suggestions come from links between entries in TanyaKanker's database, not from a medical judgement. Each suggestion includes why it appears.
Next to learn
- Colorectal Cancer
Cancer type
Reason: Related through a biomarker
- Stomach Cancer
Cancer type
Reason: Related through a biomarker
- Pancreatic Cancer
Subtype
Reason: Related through a biomarker
- Newly diagnosed lung cancer
Decision situation
Reason: Related through a biomarker
- Metastatic lung cancer
Decision situation
Reason: Related through a biomarker
- NTRK fusion
Molecular alteration
Reason: Related through a biomarker
To check
- FISH (fluorescence in situ hybridisation)
Diagnostic test
Reason: Diperiksa melalui
- Immunohistochemistry (IHC)
Diagnostic test
Reason: Diperiksa melalui
- Next-generation sequencing (NGS)
Diagnostic test
Reason: Diperiksa melalui
- Check medical report completeness
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- Upload medical reports
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