RET fusion
A rare fusion that can be targeted with selective RET inhibitors.
Parent marker: RET
Not a diagnosis and not final medical advice. Must be reviewed by a doctor.
Clinical meaning
RET fusion activates a signaling pathway that can be selectively inhibited. This group is among those with the clearest benefits if discovered.
How this finding appears in a report
Found via sequencing panel or FISH, with confirmation if necessary.
When therapy stops working
Changes in the RET kinase domain are one of the mechanisms sought after progression.
What needs verification
- Complete variant name as written in the laboratory report.
- Examination methods and types of samples used.
- Examination dates were compared with ongoing therapy.
Marker context: RET
RET fusion in non-small-cell lung cancer is discussed in the category of RET inhibitors. These findings are usually part of a broader sequencing panel.
A negative result does not always mean absent
Summary
- Gen
- RET
- Variant
- RET rearrangement
- Alteration type
- Fusion
- Discussed in
- Lung Cancer, Stomach Cancer
- Updated
- 2026-09-10
Other names in reports
RET fusion, KIF5B-RET
Drugs discussed
Treatment categories
Sources
- NCI Dictionary of Cancer Terms(lembaga)
- ClinicalTrials.gov(registry)
Clinical trials
Studies mentioning marker RET
Filtered from public study descriptions. Access status and site readiness remain unverified.
NCT01639508Phase 2Combination regimen
Cabozantinib in Patients With RET Fusion-Positive Advanced Non-Small Cell Lung Cancer and Those With Other Genotypes: ROS1 or NTRK Fusions or Increased MET or AXL Activity
Lung Cancer | biomarker: ROS1, MET, RET, NTRK
United States7 registry sites
Why this appears: Appears because it is recorded for Lung Cancer, it mentions marker ROS1.
What to verify: Acceptance of patients from outside the local country has not been verified.
- Registry
- Recruiting in registry
- Site
- Not verified
- International access
- Unknown
- Patient match
- Not assessed
Last checked 16 Oktober 2026Source ClinicalTrials.govNCT01639508Not verified
Next steps
These suggestions come from links between entries in TanyaKanker's database, not from a medical judgement. Each suggestion includes why it appears.
Next to learn
- RET
Biomarker
Reason: Related through a biomarker
- Stomach Cancer
Cancer type
Reason: Related to this page
- Lung Cancer
Cancer type
Reason: Related to this page
- Pralsetinib
Drug
Reason: Related to this page
- Selpercatinib
Drug
Reason: Related to this page
- Targeted therapy
Treatment category
Reason: Related to this page
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