TMB-high
A high tumour mutation burden value sometimes used as an additional consideration for immunotherapy.
Parent marker: TMB (tumour mutational burden)
Not a diagnosis and not final medical advice. Must be reviewed by a doctor.
Clinical meaning
High scores may add to consideration of immunotherapy, but thresholds differ between platforms and the relationship is not consistent across cancer types.
How this finding appears in a report
Generated from sequencing panels; values from different panels cannot be compared directly.
When therapy stops working
TMB values may change after therapy and need to be read along with other markers.
What needs verification
- Complete variant name as written in the laboratory report.
- Examination methods and types of samples used.
- Examination dates were compared with ongoing therapy.
Marker context: TMB (tumour mutational burden)
High TMB values in some tumors were associated with greater likelihood of benefit from immunotherapy, but this association was not consistent across cancer types. The thresholds used differ between laboratories and between platforms.
A negative result does not always mean absent
Summary
- Gen
- TMB
- Variant
- Tumor mutational burden tinggi
- Alteration type
- Scale status
- Discussed in
- Lung Cancer, Stomach Cancer, Colorectal Cancer
- Updated
- 2026-09-10
Other names in reports
TMB-H
Drugs discussed
Treatment categories
Sources
- NCI Dictionary of Cancer Terms(lembaga)
- ClinicalTrials.gov(registry)
Next steps
These suggestions come from links between entries in TanyaKanker's database, not from a medical judgement. Each suggestion includes why it appears.
Next to learn
- TMB (tumour mutational burden)
Biomarker
Reason: Related through a biomarker
- Colorectal Cancer
Cancer type
Reason: Related to this page
- Stomach Cancer
Cancer type
Reason: Related to this page
- Nivolumab
Drug
Reason: Related to this page
- Pembrolizumab
Drug
Reason: Related to this page
- Immunotherapy
Treatment category
Reason: Related to this page
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