TMB (tumour mutational burden)
Other names: tumor mutational burden, beban mutasi tumor
TMB measures how many changes are present in tumour DNA and is sometimes used as an additional consideration in immunotherapy discussion.
Not a diagnosis and not final medical advice. Must be reviewed by a doctor.
Plain explanation
TMB calculates how many changes are found when the tumor's genetic material is read. The numbers are reported as the number of mutations per unit size.
Clinical meaning
High TMB values in some tumors were associated with greater likelihood of benefit from immunotherapy, but this association was not consistent across cancer types. The thresholds used differ between laboratories and between platforms.
Testing methods
- Next-generation sequencing (NGS)
A test that reads many genes from one tumour sample to find actionable changes.
A negative result does not always mean the marker is absent
Test sensitivity differs by sample type and method. Results need to be read together with the pathology report and clinical condition.
What needs verification
- Platform and panel used, because results cannot be compared directly between platforms.
- The threshold that a laboratory uses to declare high or low.
- Compliance with other markers such as PD-L1 or MSI before interpreting the results.
Related drugs
- Pembrolizumab
Anti-PD-1 antibodies
- Nivolumab
Anti-PD-1 antibodies
A link here means the marker is often part of considering a drug category, not a recommendation to use it.
Clinical trials
Studies mentioning this marker
Filtered from public study descriptions. Access status and site readiness remain unverified.
NO DATA
No studies in the latest registry data mention this marker in their description.
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Next steps
These suggestions come from links between entries in TanyaKanker's database, not from a medical judgement. Each suggestion includes why it appears.
Next to learn
- Colorectal Cancer
Cancer type
Reason: Related through a biomarker
- Stomach Cancer
Cancer type
Reason: Related through a biomarker
- Metastatic lung cancer
Decision situation
Reason: Related through a biomarker
- Lung cancer progression after immunotherapy
Decision situation
Reason: Related through a biomarker
- TMB-high
Molecular alteration
Reason: Related through a biomarker
- Immunotherapy
Treatment category
Reason: Related through a biomarker
To check
- Next-generation sequencing (NGS)
Diagnostic test
Reason: Diperiksa melalui
- Check medical report completeness
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Review of the treatment plan
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