MGMT methylated
MGMT promoter methylation status discussed in glioma.
Parent marker: MGMT
Not a diagnosis and not final medical advice. Must be reviewed by a doctor.
Clinical meaning
Methylated status is associated with a greater likelihood of benefit from certain categories of chemotherapy in glioma, but is not the sole determinant of treatment planning.
How this finding appears in a report
Examined for tumor tissue; Reporting methods and thresholds may differ between laboratories.
When therapy stops working
The MGMT status of relapsed tissue may differ from that of the initial tumor.
What needs verification
- Complete variant name as written in the laboratory report.
- Examination methods and types of samples used.
- Examination dates were compared with ongoing therapy.
Marker context: MGMT
MGMT methylation status is frequently discussed in gliomas, particularly glioblastoma, because it influences how medical teams discuss the relative benefits of certain categories of chemotherapy. This status is not the sole determinant.
A negative result does not always mean absent
Summary
- Gen
- MGMT
- Variant
- MGMT promoter methylated
- Alteration type
- Methylation
- Discussed in
- Brain Cancer
- Updated
- 2026-09-10
Other names in reports
MGMT methylated
Drugs discussed
Treatment categories
Sources
- NCI Dictionary of Cancer Terms(lembaga)
- ClinicalTrials.gov(registry)
Next steps
These suggestions come from links between entries in TanyaKanker's database, not from a medical judgement. Each suggestion includes why it appears.
Next to learn
- MGMT
Biomarker
Reason: Related through a biomarker
- Brain Cancer
Cancer type
Reason: Related to this page
- Temozolomide
Drug
Reason: Related to this page
- Chemotherapy
Treatment category
Reason: Related to this page
- Radiotherapy
Treatment category
Reason: Related to this page
To check
- Check medical report completeness
Tool
Reason: Prepare documents that still need confirmation
- Prepare questions for your doctor
Tool
Reason: Bring clear questions to the next conversation
What you can do
- Upload medical reports
Build a case summary in twelve steps
Reason: Often the most useful next step after reading this page
- Request a second opinion
Review of the treatment plan
Reason: Relevant when a treatment plan is being considered
- Consult a navigator
A request is recorded with this page context
Reason: For asking the next step directly
Recently updated
- Leukemia
Cancer page
Date: Data revision 2026-09-10
- Brain Cancer
Cancer page
Date: Data revision 2026-09-10
- Pancreatic Cancer
Cancer page
Date: Data revision 2026-09-10
- Testing Osimertinib as a Treatment for Lung Cancers With an EGFR Exon 20 Change
NCT03191149 - Phase 2
Date: Registry update in the last 30 days (2026-10-15)
Want to follow changes on this topic? Save the page or follow the topic so it is easy to find again. View saved items.
Prepare for your next consultation
Use the free six-question tool to prepare questions for your doctor.