MGMT
Other names: MGMT promoter methylation, metilasi promotor MGMT
MGMT promoter methylation status is discussed in glioma and relates to how cells repair damage caused by certain drugs.
Not a diagnosis and not final medical advice. Must be reviewed by a doctor.
Plain explanation
MGMT is a gene that helps cells repair DNA damage. In some tumors, this gene is 'turned off' by the methylation process, making it more difficult for cells to repair damage caused by certain therapies.
Clinical meaning
MGMT methylation status is frequently discussed in gliomas, particularly glioblastoma, because it influences how medical teams discuss the relative benefits of certain categories of chemotherapy. This status is not the sole determinant.
Testing methods
- Next-generation sequencing (NGS)
A test that reads many genes from one tumour sample to find actionable changes.
- Tumour tissue biopsy
Collection of tumour tissue to confirm the diagnosis and provide material for further testing.
A negative result does not always mean the marker is absent
Test sensitivity differs by sample type and method. Results need to be read together with the pathology report and clinical condition.
What needs verification
- Examination methods used and reporting thresholds.
- The suitability of the results with the established pathological diagnosis.
- Other factors influence the treatment plan, including the general condition and location of the tumor.
Related drugs
- Temozolomide
Oral alkylating agent
A link here means the marker is often part of considering a drug category, not a recommendation to use it.
Clinical trials
Studies mentioning this marker
Filtered from public study descriptions. Access status and site readiness remain unverified.
NO DATA
No studies in the latest registry data mention this marker in their description.
Check options based on your result
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Next steps
These suggestions come from links between entries in TanyaKanker's database, not from a medical judgement. Each suggestion includes why it appears.
Next to learn
- Brain Cancer
Cancer type
Reason: Related through a biomarker
- MGMT methylated
Molecular alteration
Reason: Related through a biomarker
- Chemotherapy
Treatment category
Reason: Related through a biomarker
- Radiotherapy
Treatment category
Reason: Related through a biomarker
- Temozolomide
Drug
Reason: Targets this marker
To check
- Tumour tissue biopsy
Diagnostic test
Reason: Diperiksa melalui
- Next-generation sequencing (NGS)
Diagnostic test
Reason: Diperiksa melalui
- Check medical report completeness
Tool
Reason: Prepare documents that still need confirmation
- Prepare questions for your doctor
Tool
Reason: Bring clear questions to the next conversation
What you can do
- Upload medical reports
Build a case summary in twelve steps
Reason: Often the most useful next step after reading this page
- Request a second opinion
Review of the treatment plan
Reason: Relevant when a treatment plan is being considered
- Consult a navigator
A request is recorded with this page context
Reason: For asking the next step directly
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